People

Education
FRCP (London, 2022), MD (2015), FACC (2017), FESC (2017), FRCP (Edin, 2014), FHKAM (Medicine, 2008), FHKCP (2008), ECFMG (2006), MRCP (UK, 2003), MBChB (Hon, CUHK, 2000)

Expertise
Cardiac imaging, structural heart disease and intervention, heart failure

Research Interests
Cardiac imaging, advanced echocardiography techniques, biomedical engineering, heart valve disease, structural heart intervention, heart failure

Professor Alex Lee is a Professor of Medicine and Therapeutics at the Chinese University of Hong Kong and serves as the Director of the Echocardiography Laboratory at the Prince of Wales Hospital. In 2018, he was also appointed as the Director of the Laboratory of Cardiac Imaging and 3D Printing at the Li Ka Shing Institute of Health Sciences. Currently the Vice-President of the Asian-Pacific Association of Echocardiography, Professor Lee is an esteemed alumnus of the Mayo Clinic and has made significant contributions to cardiovascular medicine and imaging. He has published over 300 peer-reviewed articles on echocardiography and cardiovascular medicine and serves as the section editor for echocardiography for JACC: Asia. At CUHK, he is the principal investigator of more than 20 clinical trials and has received numerous prestigious accolades, including the State Ministry of Education First-Class Award, the ESC Young Investigator Award, the CUHK Research Excellence Award, the Hong Kong College of Physicians Distinguished Research Award, the Distinguished Young Fellow award, and the Richard Yu Lectureship. Recognized internationally, he was elected as an Expertscape Expert in 3D echocardiography, a testament to his pioneering contributions to the field.

1. Xu HF, Chen M, Wang Z, Huo JY, Li J, He FP, Firyuza Husanova, Li HY, Zhou DX, Zhang XC, Liu XB, Song GY, Li J, Luo JF, Guo YQ, Mou Y, Yuan S, Tao TT, Wu SJ, Teng P, Ni YM, Ma L, Pan XB, Ge JB, Lee APW, Li WD. Mid-term outcomes of K-Clip transcatheter tricuspid annuloplasty system in patients with severe functional tricuspid regurgitation. JACC Cardiovasc Interv (2024);17(23):2796-2807.
2. Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Ma CS, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesová E, Kang SM, Katova T, Kosiborod MN, Latkovskis G, Lee APW, Linssen GCM, Llamas-Esperón G, Mareev V, Martinez FA, Melenovský V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov LG, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Viswanathan P. Finerenone in heart failure with mildly reduced or preserved ejection fraction. Eur Heart J. 2024;391(16):1475-1485.
3. Solomon SD, Ostrominski JW, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Ma CS, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesová E, Kang SM, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperón G, Mareev V, Martinez FA, Melenovský V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov LG, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Viswanathan P, McMurray JJV. Baseline characteristics of patients with heart failure with mildly reduced or preserved ejection fraction: The FINEARTS-HF trial. Eur J Heart Fail. 2024;26(6):1334-1346.
4. Gao X, Luo W, Qu L, Yang M, Chen S, Lei L, Yan S, Liang H, Zhang X, Xiao M, Liao Y, Lee AP, Zhou Z, Chen J, Zhang Q, Wang Y, Xiu J. Genetic association of lipid-lowering drugs with aortic aneurysms: a Mendelian randomization study. Eur J Prev Cardiol. 2024;31(9):1132-1140.
5. Chen S, Su Y, Zhang M, Zhang Y, Xiu P, Luo W, Zhang Q, Zhang X, Liang H, Lee AP, Shao L, Xiu J. Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influencing factors. J Nanobiotechnol. 2023;21(1):e1477-3155.
6. Morais P, Fan Y, Queiros S, D’Hooge J, Lee APW, Vilaca JL. Feasibility and accuracy of automated three-dimensional echocardiographic analysis of left atrial appendage for transcatheter closure. J Am Soc Echocardiogr. 2022;35:124-133.
7. Lai LKL, So CY, Chui KL, Kam KK, Kwok KW, Wong RH, Cheung GS, Lam YY, Lee AP. Plug and clip: percutaneous repair of a perforated mitral valve complicating severe functional mitral regurgitation. JACC Cardiovasc Interv. 2022;15(4):e41-e43.
8. Mao Z, Zhao L, Huang S, Fan Y, Lee AP. Direct 3D ultrasound fusion for transesophageal echocardiography. Comput Biol Med. 2021;134:104502.
9. Fan Y, Yang F, Cheung GS, Chan AK, Wang DD, Lam YY, Chow MC, Leong MC, Kam KK, So KC, Tse G, Qiao Z, He B, Kwok KW, Lee AP. Device sizing guided by echocardiography-based three-dimensional printing is associated with superior outcomes after percutaneous left atrial appendage occlusion. J Am Soc Echocardiogr. 2019;32(6):708-719.
10. Tang Z, Fan YT, Wang Y, Jin CN, Kwok KW, Lee APW. Mitral annular and left ventricular dynamics in atrial functional mitral regurgitation: a three-dimensional and speckle-tracking echocardiographic study. J Am Soc Echocardiogr. 2019;71(2):271-280.